Department of Infectious Diseases
School of Immunology and Microbial Sciences
King’s College London
5th floor Tower Wing, Guy’s Hospital
Great Maze Pond
London SE1 9RT
We study the metabolic regulation of T cell function. My lab focuses on human T cells specific to persistent antigens, such as found in chronic viral infections and cancer, to understand how T cells fuel their extraordinary effector capacity. To approach this question in humans we have close links with clinical collaborators at King’s College Hospitals and the Guy’s and St Thomas’ Trust.
Our current projects include:
- The study of the metabolic regulation of CAR T cells
- The role of co-stimulatory domains on the metabolic regulation of chimeric antigen receptor (CAR) T cell function
- How extracellular vesicles can regulate the function of T cells post infection
We study human T cells ex vivo and in vitro, making use of different culture systems, retroviral-mediated gene transduction of T cells, multi-color flow-cytometry, high resolution microscopy, metabolic analysis and a variety of immunological, biochemical and molecular approaches.
I am also an active member of the British Society for Immunology Immunometabolism Affinity Group organizing events and meetings throughout the year.