Laboratory of Lymphocyte Signaling and Development
Babraham Institute
Babraham Research Campus
Cambridge
CB22 3AT
United Kingdon
Lab Website:
www.babraham.ac.uk/our-research/lymphocyte/michelle-linterman
Research Interests:
The germinal centre (GC) reaction forms in secondary lymphoid organs (SLOs) after infection or immunization. Its initiation and maintenance requires the collaboration of multiple different types of leukocytes, including B cells, dendritic cells (DCs), follicular helper T (Tfh) cells, follicular regulatory T (Tfr) cells and macrophages, which, by acting in concert, ultimately produce long-lived antibody secreting plasma cells and memory B cells that provide protection against subsequent infection. Our research focuses on how the different cell types in the GC function together to generate long-lasting humoral immunity.
