Laboratory of Lymphocyte Signaling and Development
Babraham Research Campus
The germinal centre (GC) reaction forms in secondary lymphoid organs (SLOs) after infection or immunization. Its initiation and maintenance requires the collaboration of multiple different types of leukocytes, including B cells, dendritic cells (DCs), follicular helper T (Tfh) cells, follicular regulatory T (Tfr) cells and macrophages, which, by acting in concert, ultimately produce long-lived antibody secreting plasma cells and memory B cells that provide protection against subsequent infection. Our research focuses on how the different cell types in the GC function together to generate long-lasting humoral immunity.