Francesco Annunziato
Meryem Aloulou
Petra Bacher
João Barata
Francesca Barone
Dirk Baumjohann
Burkhard Becher
Andreas Beilhack
Friederike Berberich-Siebelt
Luciana Berod
Barbara Bohle
Tobias Bopp
Jose Borghans
Dirk Brenner
Veit Buchholz
Ana Cumano
Carolin Daniel
Ana de Sousa
Michael Delacher
Manuel Diaz-Munoz
Gerard Eberl
Matthias Edinger
Wilfried Ellmeier
Laura Elo
Nicolas Fazilleau
Carmen Gerlach
Luis Graca
Iris Gratz
Vigo Heissmeyer
Ping-Chih Ho
Petra Hoffmann
Maike Hofmann
Andrew Hogan
Magdalena Huber
Jochen Huehn
Johannes Huppa
Matteo Iannacone
Lukas Jeker
Nicole Joller
Eliisa Kekäläinen
Ludger Klein
Andreas Krueger
Michelle Linterman
Adrian Liston
Vera Martins
Jost Meerwijk
Eóin N. McNamee
Michael Meyer-Hermann
Hans-Willi Mittrücker
Anne Müller
Luigia Pace
Esperanza Perucha
Pärt Peterson
Eliane Piaggio
Immo Prinz
Arianne Richard
Rahul Roychoudhuri
Anna Rudin
Benoit Salomon
Jannike Samson
Susan Schlenner
Kilian Schober
Katrin Schumann
Anna Schurich
Bruno Silva-Santos
Helena Soares
Tim Sparwasser
Jens Stein
Ondrej Stepanek
Jessica Strid
Femke van Wijk
Martin Vaeth
Marc Veldhoen
Lucy Walker
Thomas Wekerle
Dave Whithers
Monika Wolkers
Christina Zielinski

University of Fribourg
Department of Oncology, Microbiology and Immunology (OMI)
Chemin du Musée 5
1700 Fribourg
Switzerland
Lab Website:
Research Interests:
Our laboratory is combining multiple platforms including multicolor flow cytometry, functional in vitro assays and high-end microscopy to “shed light” on the molecular and cellular processes that govern adaptive immune responses mediated by cytotoxic CD8+ T cells. We follow three lines of investigation:
- We are examining the role of key regulators of T cell activation by using genetically modified CD8+ T cells. Our technical platforms include flow cytometry, RNA sequencing, viral infection models, immunofluorescent analysis and twophoton microscopy (2PM) of lymphoid tissue. Using software-based analysis of key parameters, we determine the critical decision-making steps at the onset of immune responses.
- We follow CD8+ T cells at their effector sites, for example in exocrine glands, skin and other non-lymphoid organs and observe how these cells contribute to host protection. A special focus is on tissue-resident memory T cells that provide a first line of defense against reinfection.
- We are applying large-scale imaging techniques, Optical Projection Tomography (OPT) and Selective Plane Illumination Microscopy (SPIM) for a quantitative analysis of adaptive immune responses by visualizing the entire 3D structure of lymph nodes and other organs during inflammation.
The combination of these approaches permits to obtain unprecedented insight into the dynamic nature of the adaptive immune system on a single cell level.