Center for Pathophysiology of Toulouse-Purpan
University of Toulouse
Our long-term research interest is to better understand how humoral responses are regulated by T lymphocytes. With our studies, we aim to identify predictive biomarkers and therapeutic targets to improve humoral responses in physiological conditions or revert humoral dysfunction associated with pathologies. In ongoing studies we address the following research topics:
- Cognate regulation of B cell responses by T Follicular Helper cells (Tfh)
- Regulation of germinal center by T Follicular Regulatory cells (Tfr)
- Transcriptional control of Tfh and Tfr cell development
The experimental strategies to address our research interests include multi-color flow-cytometry, imaging using 2-photon microscopy and imagestream and a variety of immunological tools such as next generation sequencing.