Institute of Immunology
MU Human Health Research Institute
Department of Biology
Our Mucosal Immunology group is focused on understanding the pathogenesis of chronic inflammatory diseases at barrier surfaces and the identification of novel therapeutics. Ongoing studies include:
- Chemokine and microRNA control of CD4+ T cell responses in inflammatory bowel diseases
- Impact of effector CD4+ T cells on intestinal remodeling and cross-talk with stromal cell populations (including Lymphatic vessels, Paneth cells and Fibroblasts)
- Role of CD4+ T cells in the generation and maintenance of Gut-Associated Lymphoid Tissues (secondary and tertiary) and the generation of IgA responses
We maintain a translational focus by combining pharmacologic and genetic approaches in transgenic and germ-free mice with advanced immunology and imaging techniques using clinical specimens.