Interdisciplinary Center for Clinical Research Laboratory
Center for Experimental Molecular Medicine
Department of Medicine II
Würzburg University Hospital

ZEMM, Zinklesweg 10
97078 Würzburg, Germany

Lab Website:


Research Interests:

We focus on dynamic T cell interactions after allogeneic hematopoietic cell transplantation, an often curative but also risk-associated therapy for many malignancies. In preclinical models, we explore anti-tumor mechanisms, graft-versus-host disease and graft-versus-infection mechanisms exerted by allogeneic immune cell subpopulations.
Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T lymphocytes. With our studies we aim to provide important and medical relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we explore:

  • How environmental factors and cellular interactions shape T cell responses to fight cancer, resolve inflammation and control pathogens
  • How T cell responses unfold and are spatiotemporally orchestrated by the innate immune system and in the contexture of the tissue environment
  • The interplay of defined T cell subsets

To gain better insights into these complex immune processes we employ mouse models, state-of-the-art imaging techniques, such as 3D light-sheet fluorescence microscopy (LSFM), dynamic multi-photon-microscopy (MPM), non-invasive bioluminescence imaging, multiparameter flow cytometery and molecular techniques to ultimately translate our findings into improved diagnostics and therapies.