Institute for Immunology And
Research Center for Immunotherapy (FZI)
University Medical Center Mainz
Johannes Gutenberg-University Mainz
The major focus of research in the Bopp laboratory is to understand the regulation of T cell responses in a context- and tissue-specific manner. Here, we particularly focus on the functional and molecular characterization of CD4+FOXP3+ regulatory T (TREG) cell and CD4+ T Helper (TH) cell differentiation and function. Furthermore, we are interested in non-classical ways of communication between non-hematopoietic cells and cells of myeloid and lymphoid origin. We are aiming to elucidate the role of transcription factors and transcription factor complexes in the differentiation and tissue-specific function of TREG and TH cell subsets in cancer, allergy and autoimmune disease.
To accomplish these goals we are conducting state-of-the-art methods, including several techniques for single cell Next-Generation-Sequencing, multi-color flow-cytometry, sophisticated preclinical animal models and analyses of patient material.