Institute of Biomedicine and Translational Medicine
University of Tartu
We study several aspects of the immune system and how it is regulated. Our research directions are:
- Central immune tolerance and the function of the Autoimmune Regulator (AIRE) gene in the thymus.
- Immunopathology of APECED (or APS1) disease, in which patients develop multiple endocrine autoimmune disorders and chronic mucocutaneous candidiasis.
- The role of autoantibodies to type 1 interferon and other cytokines, and their presence among autoimmune patients and in aged individuals
- Age-related changes in old individuals to understand the molecular and cellular drivers of these processes.
We combine molecular and cellular techniques including multi-color flow-cytometry, use genome-wide transcriptomic and epigenetic analyses, and single-cell technologies to study molecular regulation of immune cells.