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Molecular Pathology
Institute of Biomedicine and Translational Medicine

University of Tartu
Ravila 19
Tartu 50411

Lab Website:


Research Interests:

We study several aspects of the immune system and how it is regulated. Our research directions are:

  • Central immune tolerance and the function of the Autoimmune Regulator (AIRE) gene in the thymus.
  • Immunopathology of APECED (or APS1) disease, in which patients develop multiple endocrine autoimmune disorders and chronic mucocutaneous candidiasis.
  • The role of autoantibodies to type 1 interferon and other cytokines, and their presence among autoimmune patients and in aged individuals
  • Age-related changes in old individuals to understand the molecular and cellular drivers of these processes.

We combine molecular and cellular techniques including multi-color flow-cytometry, use genome-wide transcriptomic and epigenetic analyses, and single-cell technologies to study molecular regulation of immune cells.