Centre for Inflammation Biology and Cancer Immunology (CIBCI),
King's College London
1st floor New hunt House, King's College London
Great Maze Pond, SE1 1UL London
Our long-term research interest is to characterize molecular mechanisms that regulate the development and function of T lymphocytes. With our studies we aim to provide important and medical relevant insight into the regulation of T cell-mediated immunity. In ongoing studies we address the following research topics:
- The role of histone deacetylases in the regulation of T cell-mediated immunity
- Transcriptional control of T cell development
- Regulation of peripheral T cell function and maintenance of T cell lineage identity and integrity
The experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, retroviral-mediated gene transduction into hematopoietic stem cells, next generation sequencing and mouse molecular genetics tools.
The lab is interested on mechanisms of immune activation and tolerance in man, from molecules to cells and the whole individual. We work on CD4+ T cells, as they are the major orchestrators of the immune response, and we aim at understanding how they activate and also regulate, with focus on the interaction between cellular metabolism and immune function. Our final aim is to find new ways to modulate the human immune response, in order to restore homeostasis (which is defective in chronic inflammation) or boost the effector arm, which may benefit the body when it fights infection or cancer.
More specifically, we have described how the cholesterol biosynthesis pathway is able to modulate immune-resolution in human CD4+ T cells, by regulating the production of the anti-inflammatory cytokine IL-10. We have also evidence of the relevance of cholesterol metabolism in vivo. We think that the cholesterol biosynthesis pathway is an immunometabolic switch and we are now exploring this hypothesis in both health and disease.