Friederike Berberich-Siebelt, PD, PhD

Research Interests:

The research group has a special interest in conventional T cells and regulatory T cells.
Here, one focus lies on the expression pattern and activation as well as signal transduction of the transcription factor family ‘NFAT’, we mainly study in mice.

• The role of individual NFAT family members and their isoforms
• The influence of modifications, especially by sumoylation
• The interplay with other transcription (co-) factors
• The overall loss of NFAT expression in various immune cells

The experimental strategies to address our research interests include multi-color flow-cytometry, molecular approaches, cell culture, next generation sequencing including scRNAseq, CyTOF, virus-free CRISPR/Cas9-mediated deletions, transgenic mice and several preclinical mouse models for autoimmune diseases, organoids