Institute of Experimental Immunology,
University of Zurich
Winterthurerstrasse 190, Y36L68
Our understanding of host-pathogen interaction is primarily derived from studying how the immune system protects us from a single pathogen. In contrast, it is largely unknown how this response alters the body's ability to respond to a second infectious agent or the susceptibility to autoimmunity or cancer. Our goal is to investigate the long-term effects of pathogenic challenges on future responses. Currently, we are focusing on changes in the regulatory compartment of the adaptive immune system. Specifically we aim to:
- Analyze how regulatory T cell (Treg) function and the composition of the Treg compartment are affected by different types of infections
- Determine how a genetically modified Treg compartment affects susceptibility to infections and autoimmunity
- Investigate how co-inhibitory receptors affect pathogen persistence
To achieve this goal we use a wide variety of techniques including multicolor flow cytometry, transcriptomic approaches, in vitro immunological assays, as well as animal disease models.