Department of Hematopoiesis, Sanquin Blood Supply - Division Research, and Landsteiner Laboratory
Amsterdam University Medical Center
Our long-term research interest is to define the human T cell effector function under physiological and pathological conditions. Specifically, we aim to define the characteristics of potent cytotoxic T cells and to unravel the mechanisms that fine-tune the production of effector molecules, with a specific focus on post-transcriptional events herein. We use this information to define how T cells can be exploited for therapeutic purposes, in particular for immunotherapy of solid tumors. In ongoing studies, we study:
- The role of RNA-binding proteins in fine-tuning T cell effector function
- Defining the rules of protein translation in T cells
- Optimizing T cell therapy for treating solid tumors
The experimental strategies to address our research interests include multi-color flow-cytometry, imaging, biochemical and molecular approaches, Crispr-CAS mediated gene-editing of human T cells, transcriptomics and proteomics analyses, and machine learning.