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Institute for Medical Microbiology and Hygiene
Biomedical Research Center (BMFZ)
University of Marburg

Hans-Meerwein-Straße 2
35043 Marburg
Germany

Lab Website:

www.uni-marburg.de/fb20/medmikrobio/forschung/ag-huber/t-cell-immune-responses.html

Research Interests:

Our aim is to understand the mechanisms of immunopathological processes involving aberrated T cell function in autoimmunity, asthma or cancer. To this regard, we characterize T cell plasticity directed by specific transcriptional and/or metabolic factors with impact on immunopathology. In ongoing studies we focus on following topics:

  • Regulation of plasticity between non-cytotoxic IL-17-producing CD8+ T (Tc17) cells versus cytotoxic T lymphocytes (CTLs)
  • Transcriptional control of IL-9 producing CD4+ T (Th9) cell versus IFN-γ producing Th1 cells
  • Influence of tumor-microenvironment on CD8+ T cells and identification of factors responsible for tumor escape

To approach our research interests we include multi-color flow-cytometry, retroviral-overexpression of proteins in primary T cells, primary murine and human T cell cultures and analysis of patient material, immunological assays, metabolic assays, biochemical and molecular methods as well as pre-clinical mouse models.