Toulouse Institute for Infectious and Inflammatory Diseases (Infinity)
Our research interest lays on characterizing the post-transcriptional regulatory networks that shape gene expression during development and function of lymphocytes. In particular, we look at protein:RNA interactions as determinants for RNA molecule synthesis, stability and translation as well as modulators of protein function in the context of disease. The main axes of our research are:
- Post-transcriptional control of lymphocyte development and homeostasis
- Implication of RNA binding proteins in physiological stress responses and lymphocyte diversification
- Signaling and post-transcriptional mechanisms in lymphocyte activation
We combine the use of cell and animal models in research with multiple methodologies to assess the transcriptome, translatome and protein:RNA interactome, as well as more standardized methodologies such as multi-color flow-cytometry, gene transduction, biochemical and molecular approaches.