Medical Clinic III for Oncology,
Hematology, Immuno-Oncology and Rheumatology
University Hospital Bonn
University of Bonn
Venusberg-Campus 1
53127 Bonn
Germany
Lab Website:
Research Interests:
We are interested in elucidating the molecular and cellular mechanisms that determine T helper cell fate decisions and functions. In particular, we are interested in understanding T follicular helper (Tfh) cells, which provide essential help for potent antibody responses, and how they are related to other T helper cell subsets. In ongoing studies we address the following research topics:
- Cellular and molecular regulation of Tfh and other T helper cell subsets
- Requirements for the induction and maintenance of Tfh cells and germinal centers
- T helper cell diversity in mice and humans
The experimental strategies to address our research interests include multi-color flow-cytometry, single-cell genomics and systems immunology approaches, murine genetic and disease models, and patient-derived samples.
