Francesco Annunziato
Francesca Barone
Dirk Baumjohann
Andreas Beilhack
Barbara Bohle
Tobias Bopp
Ana Cumano
Ana de Sousa
Gerard Eberl
Matthias Edinger
Wilfried Ellmeier
Laura Elo
Nicolas Fazilleau
Luis Graca
Vigo Heissmeyer
Petra Hoffmann
Magdalena Huber
Jochen Huehn
Johannes Huppa
Matteo Iannacone
Lukas Jeker
Nicole Joller
Ludger Klein
Andreas Krueger
Michelle Linterman
Adrian Liston
Vera Martins
Eóin N. McNamee
Michael Meyer-Hermann
Anne Müller
Luigia Pace
Pärt Peterson
Esperanza Perucha
Anna Rudin
Benoit Salomon
Jannike Samson
Kilian Schober
Katrin Schumann
Tim Sparwasser
Ondrej Stepanek
Jessica Strid
Femke van Wijk
Marc Veldhoen
Lucy Walker
Thomas Wekerle
Dave Whithers
Christina Zielinski
Cimi-Paris
University Pierre et Marie Curie and Inserm
91 Bd de l'hopital
75013 Paris
France
Lab Website:
Research Interests:
Our long-term research interest is to study the role and biology of Foxp3 regulatory T cells (Treg) at steady state and in various immunopathologies (multiple sclerosis, type 1 and type 2 diabetes, colitis) and cancer. More specifically, we analyze the role of TNFR2, ICOS, NF-kB, mTOR and AMPK expressed by Tregs at steady state and in various pathologies using conditional KO mice. Our specific objectives are thus to :
- Analysis the mechanism of the TNF-dependent Treg boost. Since NF-kB is considered as the major TNFR-induced transduction signal, we have generated mice that have a conditional KO for RelA or RelB in Tregs.
- Analysis the effect of inflammation induced by immune adjuvants on Treg biology.
- Analysis the role of cellular metabolism in Treg biology.
- Analysis the role of ICOS expressed by Treg in tumor immunology.
The experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, next generation sequencing and mouse molecular genetics tools.
