Logo Inserm

Cimi-Paris
University Pierre et Marie Curie and Inserm

91 Bd de l'hopital
75013 Paris
France

Lab Website:

cimi-paris.upmc.fr/en/teams/treg-biology-and-therapy.html

Research Interests:

Our long-term research interest is to study the role and biology of Foxp3 regulatory T cells (Treg) at steady state and in various immunopathologies (multiple sclerosis, type 1 and type 2 diabetes, colitis) and cancer. More specifically, we analyze the role of TNFR2, ICOS, NF-kB, mTOR and AMPK expressed by Tregs at steady state and in various pathologies using conditional KO mice. Our specific objectives are thus to :

  • Analysis the mechanism of the TNF-dependent Treg boost. Since NF-kB is considered as the major TNFR-induced transduction signal, we have generated mice that have a conditional KO for RelA or RelB in Tregs.
  • Analysis the effect of inflammation induced by immune adjuvants on Treg biology.
  • Analysis the role of cellular metabolism in Treg biology.
  • Analysis the role of ICOS expressed by Treg in tumor immunology.

The experimental strategies to address our research interests include multi-color flow-cytometry, a variety of immunological tools, biochemical and molecular approaches, next generation sequencing and mouse molecular genetics tools.