Center for Medicine
Department of Medicine II, Gastroenterology, Hepatology, Endocrinology and Infectious Diseases
Medical Center – University of Freiburg
Hugstetter Str. 55
We are interested in translational questions concerning the cytotoxic cellular immune response in viral infections and cancer. A main focus of our work in the last years relates to mechanisms underlying the functional adaptation of T cells and NK cells in the context of chronic viral hepatitis caused by hepatitis B and C viruses (HBV and HCV) and in liver cancer. With these studies we aim to provide rationales for the identification of biomarkers and potential immunotherapeutic approaches. In addition, we are interested in understanding shared and diverging principles of T cell and NK cell memory in chronic versus self-limiting viral infections with HBV, HCV, Influenza A virus, cytomegalovirus (CMV) , Epstein-Barr virus (EBV) and most recently SARS-CoV-2 and mRNA vaccination.
The experimental strategies to address our research interests cover state-of-the-art immunological assays including high dimensional flow cytometry and cutting-edge single cell technologies.