Aloulou
Annunziato
Bacher
Barata
Barone
Baumjohann
Becher
Beilhack
Berberich-Siebelt
Berod
Bohle
Bopp
Borghans
Brenner
Buchholz
Cumano
Daniel
De Sousa
Delacher
Diaz-Munoz
Dominguez-Villar
Eberl
Edinger
Ellmeier
Elo
Fazilleau
Genescà
Gerlach
Graca
Gratz
Heissmeyer
Ho
Hoffmann
Hofmann
Hogan
Huber
Huehn
Huppa
Iannacone
Jeker
Joller
Kekäläinen
Klein
Krueger
Lahesmaa
Linterman
Liston
Martins
McNamee
Meerwijk
Meyer-Hermann
Mittrücker
Müller
Pace
Perucha
Peterson
Piaggio
Prinz
Richard
Roychoudhuri
Rudin
Salomon
Samson
Schlenner
Schober
Schumann
Schurich
Silva-Santos
Soares
Sparwasser
Stein
Stepanek
Strid
Vaeth
Van Wijk
Veldhoen
Walker
Wekerle
Whithers
Wolkers
Zielinski
Department Experimental Immunology,
Helmholtz Centre for Infection Research
Inhoffenstr. 7
38124 Braunschweig
Germany
Lab Website:
Research Interests:
Our long-term research interest is to identify cellular players and molecular factors controlling CD4+ helper T cell differentiation and function with the final aim to discover novel biomarkers and molecular targets in order to develop therapeutic approaches for the selective modulation of helper T cell responses. Key expertise lies in multi-color flow cytometry, transcriptomic and epigenetic profiling (RNA seq, scRNA seq, Bi seq, ATAC seq), tailored epigenetic modulation of immune cells, as well as murine infection models. Amongst others, we are presently addressing the following research topics:
- Epigenetic fixation of Foxp3 expression in regulatory T cells
- Epigenetic signatures of helper T cell subsets
- Dynamics of regulatory and effector T cells during viral and bacterial infections
- Role of microbiota for the imprinting of tolerogenic properties in stromal cells of gut-draining lymph nodes
