Division of Immunology,
Department of Pathology
University of Cambridge
Tennis Court Road
Cambridge, CB2 1QP
T cells drive immune activation and promote clearance of infections and cancer. However, their function can provoke autoimmune and allergic inflammation. The immune system therefore employs a variety of suppressive mechanisms, known as immunoregulatory mechanisms, to restrain excessive T cell activation and prevent autoimmune and allergic inflammation. It is now known that such suppressive mechanisms inhibit anti-tumour immunity to drive deleterious immunosuppression in cancer. Immunoregulatory mechanisms therefore function as ‘brakes’ within the immune system and have important consequences in infection, inflammation and cancer.
Our research aims to uncover the molecular and cellular mechanisms underpinning immune regulation and cancer immunosuppression. Fundamental discovery in the field of immunoregulation will pave the way for new therapies aimed at manipulating immune function in patients with autoimmunity and cancer.
We are particularly interested in the following research topics:
- Regulatory T (Treg) cell development and function
- Suppression of T cell immunity in cancer
- T cell maintenance and dysfunction