Institute for Immunology at the Biomedical Center of the Ludwig-Maximilians-University, Munich
Grosshaderner Str. 9
Our goal is to decipher the molecular mechanisms that control T helper cell differentiation and effector function. In these gene expression programs we focus on post-transcriptional regulation. In ongoing studies we address the following research topics:
- Decipher the physical interaction and functional cooperation of trans-acting factors and cis-elements.
- Investigate how T cell receptor-induced expression or modifications of mRNA or proteins affect cell fate decisions.
The experimental strategies to address our research interests include mouse genetics, immunology, flow cytometry, primary T cell cultures, gene expression via retroviral transduction as well as gene-editing with Crispr/Cas9. Furthermore, we employ sequencing of mRNA, of ribosome-protected RNA fragments as well as of RNA from crosslink and immunoprecipitations experiments to determine genome-wide the regulation of mRNA expression and translation as well as protein/RNA-interactions.