Aloulou Annunziato Bacher Barata Barone Baumjohann Becher Beilhack Berberich-Siebelt Berod Bohle Bopp Borghans Brenner Buchholz Cumano Daniel De Sousa Delacher Diaz-Munoz Eberl Edinger Ellmeier Elo Fazilleau Gerlach Graca Gratz Heissmeyer Ho Hoffmann Hofmann Hogan Huber Huehn Huppa Iannacone Jeker Joller Kekäläinen Klein Krueger Lahesmaa Linterman Liston Martins McNamee Meerwijk Meyer-Hermann Mittrücker Müller Pace Perucha Peterson Piaggio Prinz Richard Roychoudhuri Rudin Salomon Samson Schlenner Schober Schumann Schurich Silva-Santos Soares Sparwasser Stein Stepanek Strid Vaeth Van Wijk Veldhoen Walker Wekerle Whithers Wolkers Zielinski

Lukas Jeker, MD PhD

Assistant Professor of Experimental Transplantation Immunology & Nephrology

Email:

lukas.jeker@unibas.ch

Molecular Immune Regulation lab
Department of Biomedicine
Basel University Hospital and University of Basel

Hebelstrasse 20
CH-4031 Basel
Switzerland

Lab Website:

https://biomedizin.unibas.ch/en/research/research-groups/jeker-lab/

Research Interests:

Work in our lab aims for a better understanding of molecular mechanisms operational in T cells to maintain immune regulation. We are particularly interested in CD4⁺ T cells with a special focus on follicular helper T cells (T_FH) and regulatory T cells (Treg). We have previously shown that microRNAs are important regulators of genetic networks in T cells. Current work aims to investigate in further detail how microRNAs contribute to T cell function and immune regulation.

We specifically address the following research topics:

microRNAs as potential pharmacologic targets for immune modulation
T cell intrinsic genetic networks controlled by microRNAs
Gene repair and enhancement of T cell function through genome engineering

We employ multi-color flow-cytometry, mouse in vivo genetics, high-throughput screening, -omics approaches and genome engineering in our routine work. Our longterm goals are to translate basic research findings to novel clinical concepts.