News
September 2020
New publication of Lucy Walker in Nature Immunology
Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes. PMID: 32747817.
August 2020
New publication of Johannes Huppa in Nature Immunology
Inefficient CAR-proximal signaling blunts antigen sensitivity. PMID: 32632291.
August 2020
New publication of Ondrej Stepanek in EMBO Journal
Systematic analysis of the IL‐17 receptor signalosome reveals a robust regulatory feedback loop. PMID: 32696476.
June 2020
New publication of Christina Zielinski (in collaboration with TCCE members Jochen Huehn, Magdalena Huber and Dirk Baumjohann) in Journal of Clinical Investigation
Salt Generates Anti-Inflammatory Th17 Cells but Amplifies Their Pathogenicity in Pro-Inflammatory Cytokine Microenvironments. PMID: 32484796.
May 2020
Members of TCCE Europe received funding for a Marie Skłodowska-Curie Actions Integrated Training Network (ITN) "ENLIGHT-TEN+"
This network will
- integrate cross-disciplinary and highly innovative technologies to generate a novel view of tissue-resident T cells and understand the microenvironmental and molecular factors shaping their unique functional properties with unprecedented resolution;
- will apply this understanding to immune-mediated pathologies allowing us to selectively manipulate tissue-resident T cells in disease; and
- foster a new generation of enthusiastic young researchers able to analyse next-generation-sequencing data and to implement novel concepts of T cell biology into biomedical applications.
The network is coordinated by Jochen Huehn and among other participating PIs are also TCCE members Wilfried Ellmeier, Laura Elo, Luis Graca, Ludger Klein, Michelle Linterman, Michael Meyer-Hermann, Pärt Peterson, Benoit Salomon, Janneke Samson, Marc Veldhoen, and Lucy Walker part of the ENLIGHT-TEN+ ITN. The program is expected to start in 03/2021.
May 2020
New publication of TCCE member Marc Veldhoen in Nature Immunology
Type 1 T reg Cells Promote the Generation of CD8+ Tissue-Resident Memory T Cells. PMID: 32424367.
May 2020
TCCE members organized a virtual meeting to discuss potential collaborations on projects related to COVID-19.
March 2020
New publication of Matteo Iannacone in Nature Immunology
Spatiotemporal Regulation of Type I Interferon Expression Determines the Antiviral Polarization of CD4+ T Cells. PMID: 32066949.
March 2020
New publication of Nicole Joller in Nature Communications
Rapid Expansion of Treg Cells Protects From Collateral Colitis Following a Viral Trigger. PMID: 32251280.
February 2020
New publication of Michelle Linterman in Science Translational Medicine
Immune System Development Varies According to Age, Location, and Anemia in African Children. PMID: 32024802.
January 2020
TCCE members Nicola Fazilleau and Michelle Linterman organize a the 3rd Germinal Center Workshop, which will take place on June 8, 2020 in Paris. For more information, please visit: here. Note: Due to the COVID-19 Situation the workshop has been postponed.
January 2020
TCCE member Andreas Beilhack received funding for an Else-Kröner-Stiftung Graduiertenkolleg (PhD program)
The PhD program in coordinated by Thomas Beilhack and the aim of the Else-Kröner Research College "Immunocontrol" is to provide a structured, clinical and science-oriented education in the field of immunology. The link between basic immunological research and translational conversion is to be strengthened by exemplarily demonstrating all steps from the identification of suitable target structures to the first clinical application to patients within the framework of the research college. For more information see: here.
December 2019
New publication of Magdalena Huber (in collaboration with TCCE members Tobias Bopp and Christina Zielinski) in Nature Communications
IL-17+ CD8+ T Cell Suppression by Dimethyl Fumarate Associates With Clinical Response in Multiple Sclerosis: PMID: 31844089.
September 2019
New publication of Janneke Samsom in Mucosal Immunology
IL-10 Signaling in Dendritic Cells Controls IL-1β-mediated IFNγ Secretion by Human CD4+ T Cells: Relevance to Inflammatory Bowel Disease. PMID: 31417161.
May 2019
New publication of Ludger Klein in Journal of Experimental Medicine
Aire-expressing ILC3-like Cells in the Lymph Node Display Potent APC Features. PMID: 30918005.
Mai 2019
New publication of Gerard Eberl (in collaboration with TCCE member Tim Sparwasser) in Immunity
A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. PMID: 30902637.
March 2019
New publication of Janneke Samsom in Mucosal Immunology
IL-10 Signaling Prevents Gluten-Dependent Intraepithelial CD4+ Cytotoxic T Lymphocyte Infiltration and Epithelial Damage in the Small Intestine. PMID: 30542112.
February 2019
New publication of Christina Zielinski in Science Translational Medicine
Sodium Chloride Is an Ionic Checkpoint for Human TH 2 Cells and Shapes the Atopic Skin Microenvironment. PMID: 30787167.
January 2019
New publication of Adrian Liston in Blood
01/2019 – Murine Myeloproliferative Disorder as a Consequence of Impaired Collaboration Between Dendritic Cells and CD4 T Cells. PMID: 30333120.
December 2018
Wilfried Ellmeier received funding of the Austrian Science Fund for a Special Research Program (SFB)
HDACs as regulators of T cell-mediated immunity in health and disease. This is a research network formed by an interdisciplinary consortium of eight research groups, of which seven are located in Vienna and one in Salzburg. The overall aim of this 8-year SFB research program and consortium is to provide an immunological and molecular rationale for using sub-class-specific and isoform-selective HDAC inhibitors in the treatment of T-cell-mediated diseases. For more information: click here.
December 2018
New publication of Tobias Bopp in Nature Immunology
Tumor Immunoevasion via Acidosis-Dependent Induction of Regulatory Tumor-Associated Macrophages. PMID: 30397348.
October 2018
New publication of Wilfried Ellmeier in Nature Reviews Immunology
Histone Deacetylase Function in CD4+ T Cells. PMID: 30022149.
September 2018
New publication of Tim Sparwasser in Cell Metabolism
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. PMID: 30043753.
September 2018
new publication of TCCE member Jochen Huehn in Nature Communication
Neonatally Imprinted Stromal Cell Subsets Induce Tolerogenic Dendritic Cells in Mesenteric Lymph Nodes. PMID: 30254319.
New publication of Johannes Huppa in Nature Immunology
Monomeric TCRs Drive T Cell Antigen Recognition. PMID: 29662172.
June 2019
New paper published by Lucy Walker
TCCE member Lucy Walker published a new paper in Science Immunology that reveals that CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells. For more information see: www.ncbi.nlm.nih.gov/pubmed/31152091 (opens in new window).
January 2018
Kick-off meeting of the TCC_EUROPE study group
Satellite meeting on the occasion of the European Congress of Immunology - ECI 2018 in Amsterdam.
Saturday, 1st of September 2018, starting at 13:00 at the Waag Society (waag.org/en), Amsterdam, Netherlands.
In case you are interested to participate at the Kick-Off-Meeting, please contact the coordinator Wilfried Ellmeier via wilfried.ellmeier@meduniwien.ac.at.
