Aloulou Annunziato Bacher Barata Barone Baumjohann Becher Beilhack Berberich-Siebelt Berod Bohle Bopp Borghans Brenner Buchholz Cumano Daniel De Sousa Delacher Diaz-Munoz Eberl Edinger Ellmeier Elo Fazilleau Gerlach Graca Gratz Heissmeyer Ho Hoffmann Hofmann Hogan Huber Huehn Huppa Iannacone Jeker Joller Kekäläinen Klein Krueger Lahesmaa Linterman Liston Martins McNamee Meerwijk Meyer-Hermann Mittrücker Müller Pace Perucha Peterson Piaggio Prinz Richard Roychoudhuri Rudin Salomon Samson Schlenner Schober Schumann Schurich Silva-Santos Soares Sparwasser Stein Stepanek Strid Vaeth Van Wijk Veldhoen Walker Wekerle Whithers Wolkers Zielinski

Iris Gratz, PhD

Associate Professor

Email:

iris.gratz@plus.ac.at

Department of Biosciences and Medical Biology
University of Salzburg

Hellbrunnerstrasse 34
5020 Salzburg
Austria

Lab Website:

www.plus.ac.at/gratz

Research Interests:

The principal goal of our research is to understand the role of cutaneous T cells in skin inflammation, wound healing and cancer. Specifically, we aim to:

Understand the mechanisms of T cell differentiation and regulation of T cell-mediated immunity in (auto)inflammatory settings and
Elucidate mechanisms of disease pathology in patients with inflammatory skin diseases.

We utilize organotypic 3D-skin cultures, mouse models of T cell-mediated skin inflammation and unique humanized xenografting mouse models to elucidate mechanisms of immune regulation and to perform preclinical studies with the goal to develop novel therapeutic strategies to treat skin diseases.

Discovered the concept of tissue-resident memory regulatory T cells (Treg)
Elucidated the mechanisms of generation of peripheral Treg cells
Uncovered the recirculation behavior human skin resident memory T cells (T_RM)
Developed a novel skin-humanized mouse model to study human skin T_RM in vivo