Laboratory of Human Immunobiology and Pathogenesis
Nova Medical School
Nova University of Lisbon
Rua Câmara Pestana 6
Using human samples, we aim at deciphering the molecular mechanisms underpinning T cell regulation by distinct tissue microenvironments, including determining key factors driving the sex-bias in immune responses.
Our research is divided in two fundamental axis:
- Addressing how T cell function varies throughout life-stages from pregnancy to the elderly
- Understanding the tissue- and cell-specific factors controlling the induction of protective versus pathogenic immunity
Experimentally, we combine detailed clinical information with multi-parameter flow-cytometry, microscopy, biochemical and molecular approaches, genetic tools and next-generation sequencing.