Instituto de Medicina Molecular
Faculdade de Medicina da Universidade de Lisboa
Avenida Professor Egas Moniz
Our long-term research interest is understand the maintenance, activation, interaction and differentiation of T lymphocytes found at epithelial barriers, especially the intestine. With our studies we aim to provide insights in the regulation of immunity and how aberrant activation may cause and contribute to disorders such as autoimmunity, allergy and cancer. In ongoing studies we address the following research topics:
- The biology of intraepithelial lymphocytes
- The role of the arylhydrocrabon receptor in T cell immunity
- The interplay between T cell subsets in the intestine
The experimental strategies to address our research interests include multi-color flow-cytometry and microscopy, a variety of immunological tools, biochemical and molecular approaches, next generation sequencing and mouse molecular genetics tools.