Ondrej Stepanek

Research Interests:

We elucidate how T cells make the proper fate decisions to elicit a potent immune protection and maintain self-tolerance at the same time. Our current research projects focus on the mechanisms of T-cell signaling via antigenic and germ-line encoded receptors, discovery and characterization of particular T-cell subsets, and mechanisms of signaling induced by cytokines and co-stimulation receptors. Moreover, we study the biology of a protein complex called BBSome in immune cells and ciliated cells, to understand a rare disease called Bardet-Biedl Syndrome.