ENLIGHT-TEN+ is a network of 15 beneficiaries and 8 partner organisations from 10 European countries, all with a rich track record in collaborative research and training. The network combines diverse expertise on T cell biology, big-data-generating technologies, cutting-edge bioinformatic tools, preclinical models and patient cohort studies. ENLIGHT-TEN+ was designed to deliver a unique research & training programme within an international, cross-disciplinary, intersectoral and highly innovative environment. For the ENLIGHT-TEN+ consortium, leading scientists from academia and experts from industry were carefully selected to bring a balanced portfolio of expertise bridging in-depth knowledge of TRM cells in health and disease, tailored modulation of T cell function in translational approaches, through to bioinformatic analysis of large datasets.
ENLIGHT-TEN+ will empower its ESRs to take advantage of emerging technologies to uncover novel aspects of TRM cells in health and disease. The planned research projects will pave the way for the identification of novel biomarkers of immune-mediated pathologies and new therapeutic targets, enabling ENLIGHT-TEN+’s biopharmaceutical companies (Bayer AG, Miltenyi Biotec, Hycult Biotech, InSCREENeX, CRISPR Therapeutics) to develop novel diagnostic tests and therapeutic concepts, respectively. Given the importance of bioinformatic analysis within this programme, the involvement of two leading bioinformatics companies (IBM Research Zurich, QIAGEN Aarhus) is a major asset to our network and demonstrates the intersectoral strength of ENLIGHT-TEN+. Furthermore, the ESRs will benefit from the excellent training expertise and facilities of the European Bioinformatics Institute (EBI), and all ESRs will receive training in research ethics through the involvement of the Centre for Ethics & Law in the Life Sciences (CELLS). Finally, the ESRs will learn how to actively communicate the project outcome and its impact to the general public by the making of science videos for a wider audience with professional support of the European Academy of Science Films (EURASF) and by getting involved in the ‘Artists in the lab’ initiative1 of Cultivamoscultura.