Imperial College London

Imperial College London

Department of Infectious Disease

Immunology and Infection, room 117
Norfolk Place, St. Mary's campus
London, W2 1PG

Lab Website:

www.mdvlab.org

Research Interests:

Our laboratory is interested in understanding the mechanisms that control human CD4+ T cell responses and regulatory T cell function in homeostasis, and how these mechanisms are impaired in autoimmune diseases and chronic viral infections. We are currently working on the following research topics:

  • The role of TNF signaling in the maintenance of regulatory T cell identity in health and disease
  • The immune-metabolic mechanisms that underlie the natural protection to T1D associated to specific HLA haplotypes
  • The mechanisms of T cell dysfunction in HTLV-1-induced myelopathy

We use novel approaches to analyze antigen-specific T cells ex vivo and in vitro from tissue and blood samples from healthy individuals and people with disease, CRISPR/Cas9 technologies for gene editing and a variety of other assays to interrogate the function of T cells.