June 2019

New paper published by Lucy Walker

TCCE member Lucy Walker published a new paper in Science Immunology that reveals that CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells. For more information see: PubMed link (opens in new window).

December 2018

TCCE member Lukas Jeker receives ERC consolidator grant.

For details see ⯈website of the University of Basel. (Website opens in a new Window)

January 2018

Kick-off meeting of the TCC_EUROPE study group

Satellite meeting on the occasion of the European Congress of Immunology - ECI 2018 in Amsterdam.

Saturday, 1st of September 2018, starting at 13:00 at the Waag Society (waag.org/en), Amsterdam, Netherlands

See here

The overarching research interest of the EFIS-IL study group T CELL CONNECT EUROPE (TCC_EUROPE) is to study fundamental aspects of T cell-mediated immunity in health & disease to provide new concepts of T cell-based immunotherapies. TCC_EUROPE will connect basic and clinical researchers in the field of T cell biology to foster the development of interdisciplinary and collaborative translational approaches.

Research area

Understanding and altering T cell differentiation, homeostasis and memory formation is key for therapeutic intervention in a wide range of immune-mediated pathologies, including chronic inflammation, autoimmunity, allergy, and transplant rejection, for combating (emerging) infectious diseases and cancers as well as for restoring/maintaining immune function in the aging immune system. A better understanding of the cellular and molecular control of T cell development & function is essential for the development of novel diagnostic tools and vaccination strategies, as well as for improved and novel approaches in T cell-based therapies. In addition, the impressive recent developments of –omics, imaging as well as genetic manipulation technologies (single-cell RNA-seq, epigenomics, proteomics, metabolomics, high-resolution microscopy, Crispr/Cas9, just to name a few) is revolutionizing the way of how T cell function in health & disease can be analyzed. At the same time, it is clear that an integrated use of this wide range of techniques cannot be handled by a single laboratory, but rather requires transnational interdisciplinary collaborative approaches. The aim of TCC_EUROPE is to connect basic and clinical researchers in the field of T cell biology to foster the development of translational collaborations.

Participating principal investigators

The core group at the time of the establishment of the network in the beginning of 2018 is consisting of 33 principal investigators (PIs) from twelve countries and the activities are coordinated by a group of six researchers from five countries. To foster and intensify collaborations across Europe, TCC_EUROPE is open to constantly include new members in the TCC_EUROPE study group, in particular junior PIs working in the field of T cell biology are encouraged to participate in TCC_EUROPE activities.

Anticipated outcome

It is expected that the interactions of European T cell immunologists, clinical researchers as well as the inclusion of junior PIs together with the important topics addressed by TCC_EUROPE members will open new opportunities for collaborations, including submissions of research proposals within the new EU framework program 9 (FP9).